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  1. Surgical ovarian ablation was among the earliest approaches to adjuvant therapy in premenopausal breast cancer patients; however, the success of tamoxifen in treatment of metastatic breast cancer in pre and postmenopausal women eventually led to its introduction as the main form of endocrine adjuvant therapy in premenopausal breast cancer patients in the latter decades of the twentieth century how to beat tamoxifen weight gain

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